Research Papers: Imaging

Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography

[+] Author Affiliations
Molly L. Flexman, Jacqueline E. Gunther

Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027

Hyun K. Kim, Elise Desperito

Columbia University Medical Center, Department of Radiology, 630 West 168th Street, New York, New York 10032

Emerson A. Lim, Maria C. Alvarez, Kevin Kalinsky, Dawn L. Hershman

Columbia University Medical Center, Department of Medicine, 161 Fort Washington Avenue, New York, New York 10032

Andreas H. Hielscher

Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027

Columbia University Medical Center, Department of Radiology, 630 West 168th Street, New York, New York 10032

Columbia University, Department of Electrical Engineering, 1300 S.W. Mudd, 500 West 120th Street, New York, New York 10027

J. Biomed. Opt. 18(9), 096012 (Sep 18, 2013). doi:10.1117/1.JBO.18.9.096012
History: Received April 5, 2013; Revised July 20, 2013; Accepted August 2, 2013
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Abstract.  Diffuse optical tomography (DOT) is a noninvasive, nonionizing imaging modality that uses near-infrared light to visualize optically relevant chromophores. A recently developed dynamic DOT imaging system enables the study of hemodynamic effects in the breast during a breath-hold. Dynamic DOT imaging was performed in a total of 21 subjects (age 54±10years) including 3 healthy subjects and 18 subjects with benign (n=8) and malignant (n=14) masses. Three-dimensional time-series images of the percentage change in oxygenated and deoxygenated hemoglobin concentrations ([HbO2] and [Hb]) from baseline are obtained over the course of a breath-hold. At a time point of 15 s following the end of the breath-hold, [Hb] in healthy breasts has returned to near-baseline values (1.6%±0.5%), while tumor-bearing breasts have increased levels of [Hb] (6.8%±3.6%, p<0.01). Further, healthy subjects have a higher correlation between the breasts over the course of the breath-hold as compared with the subjects with breast cancer (healthy: 0.96±0.02; benign: 0.89±0.02; malignant: 0.78±0.23, p<0.05). Therefore this study shows that dynamic features extracted from DOT measurements can differentiate healthy and diseased breast tissues. These features provide a physiologic method for identifying breast cancer without the need for ionizing radiation.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Molly L. Flexman ; Hyun K. Kim ; Jacqueline E. Gunther ; Emerson A. Lim ; Maria C. Alvarez, et al.
"Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography", J. Biomed. Opt. 18(9), 096012 (Sep 18, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.9.096012


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