Research Papers: Imaging

Optimization and extraction of functional information from in vitro flow models using dual-beam spectral-domain optical coherence tomography cross-correlation analysis

[+] Author Affiliations
Susan M. Daly

University of Limerick, Department of Physics & Energy, Ireland

Christophe Silien

University of Limerick, Department of Physics & Energy, Ireland

University of Limerick, Materials and Surface Science Institute, Ireland

Martin J. Leahy

National University of Ireland, School of Physics, Tissue Optics and Microcirculation Imaging Group, Galway, Ireland

J. Biomed. Opt. 18(10), 106003 (Oct 02, 2013). doi:10.1117/1.JBO.18.10.106003
History: Received June 14, 2013; Revised August 23, 2013; Accepted August 28, 2013
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Abstract.  As in vivo flow behavior can be pulsatile, intermittent, and/or otherwise changeable with time, the ability to provide clinicians with a means of real-time visualization and functional assessment of structures is of particular importance. The discernment of pulsatile flow behavior using a dual-beam spectral domain optical coherence tomography system (db-SdOCT) by quasi-simultaneous measurement by two planes of illumination is demonstrated. By cross-correlation analysis, it is possible to compute velocity metrics pertaining to flowing particle motion, without a priori angular knowledge. This is the first application of cross-correlation-based dynamic assessment for the extraction of pulsatile behavior in an in vitro environment using an optimized db-SdOCT system. The experimental results outlined have shown the db-SdOCT system and its associated algorithms to be successful in the discernment of intermittent pulsatile flow behavior in in vitro models, concurrent to yielding velocity values in good agreement with that of the applied flow rate.

© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Susan M. Daly ; Christophe Silien and Martin J. Leahy
"Optimization and extraction of functional information from in vitro flow models using dual-beam spectral-domain optical coherence tomography cross-correlation analysis", J. Biomed. Opt. 18(10), 106003 (Oct 02, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.106003


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