Special Section on Optical Elastography and Measurement of Tissue Biomechanics

Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo

[+] Author Affiliations
Jiasong Li, Shang Wang, Manmohan Singh, Floredes M. Menodiado

University of Houston, Department of Biomedical Engineering, 4800 Calhoun Road, Houston, Texas 77004

Ravi Kiran Manapuram, Salavat Aglyamov, Stanislav Emelianov

The University of Texas at Austin, Department of Biomedical Engineering, 107 W. Dean Keeton Street Stop C0800, Austin, Texas 78712

Michael D. Twa

University of Houston, College of Optometry, 505 J. Davis Armistead Building, Houston, Texas 77204-2020

Kirill V. Larin

University of Houston, Department of Biomedical Engineering, 4800 Calhoun Road, Houston, Texas 77004

University of Houston, Department of Mechanical Engineering, 4800 Calhoun Road, Houston, Texas 77004

Baylor College of Medicine, Department of Molecular Physiology and Biophysics, One Baylor Plaza, Houston, Texas 77030

J. Biomed. Opt. 18(12), 121503 (Oct 02, 2013). doi:10.1117/1.JBO.18.12.121503
History: Received May 22, 2013; Revised August 31, 2013; Accepted September 6, 2013
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Abstract.  We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Jiasong Li ; Shang Wang ; Ravi Kiran Manapuram ; Manmohan Singh ; Floredes M. Menodiado, et al.
"Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo", J. Biomed. Opt. 18(12), 121503 (Oct 02, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.12.121503


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