Research Papers: Sensing

Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications

[+] Author Affiliations
Denis D. Arslanov, Marius Spunei, Julien Mandon, Simona M. Cristescu, Frans J. M. Harren

Radboud University Nijmegen, Life Science Trace Gas Research Group, Molecular and Laser Physics, Institute for Molecules and Materials, Nijmegen, The Netherlands

Maria P. P. Castro

Universidade Estadual do Norte Fluminense Darcy Ribeiro, Centro de Ciência e Tecnologia, Laboratorio de Ciências Fisicas, Campos, Brazil

Noortje A. Creemers, Anne H. Neerincx

Radboud University Nijmegen, Life Science Trace Gas Research Group, Molecular and Laser Physics, Institute for Molecules and Materials, Nijmegen, The Netherlands

Radboud University Nijmegen Medical Centre, Department of Pediatrics, Nijmegen, The Netherlands

Peter Merkus

Radboud University Nijmegen Medical Centre, Department of Pediatrics, Nijmegen, The Netherlands

J. Biomed. Opt. 18(10), 107002 (Oct 02, 2013). doi:10.1117/1.JBO.18.10.107002
History: Received June 21, 2013; Revised September 4, 2013; Accepted September 6, 2013
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Abstract.  A versatile, continuous wave, optical parametric oscillator is used in combination with photoacoustic spectroscopy for long-term trace gas experiments of volatile compounds emitted by biological samples. The optical parametric oscillator-based spectrometer (wavelength near 3 μm, 8-MHz linewidth, output power 1W) is successfully tested for the detection of hydrogen cyanide (HCN) emission from clover leaves, and Pseudomonas bacteria; in addition, the presence of HCN in exhaled human breath is measured. For specific experiments, the spectrometer is operated continuously up to 10 days and has a detection limit of 0.4 parts-per-billion volume of HCN in air over 10 s, using the P8 rotational line in the ν3 vibrational band of HCN at 3287.25cm1. This results in an overall sensitivity of the system of 2.5×109cm1Hz1/2.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Denis D. Arslanov ; Maria P. P. Castro ; Noortje A. Creemers ; Anne H. Neerincx ; Marius Spunei, et al.
"Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications", J. Biomed. Opt. 18(10), 107002 (Oct 02, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.107002


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