Research Papers: General

Noninvasive evaluation of electrical stimulation impacts on muscle hemodynamics via integrating diffuse optical spectroscopies with muscle stimulator

[+] Author Affiliations
Yu Shang, Yu Lin, Brad A. Henry, Ran Cheng, Chong Huang, Guoqiang Yu

University of Kentucky, Department of Biomedical Engineering, Lexington, Kentucky 40506

Li Chen, Brent J. Shelton

University of Kentucky, Department of Biostatistics, Lexington, Kentucky 40536

Karin R. Swartz

University of Kentucky, Department of Neurosurgery, Lexington, Kentucky 40536

Sara S. Salles

University of Kentucky, Department of Physical Medicine and Rehabilitation, Lexington, Kentucky 40536

J. Biomed. Opt. 18(10), 105002 (Oct 04, 2013). doi:10.1117/1.JBO.18.10.105002
History: Received April 10, 2013; Revised August 28, 2013; Accepted September 4, 2013
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Abstract.  Technologies currently available for the monitoring of electrical stimulation (ES) in promoting blood circulation and tissue oxygenation are limited. This study integrated a muscle stimulator with a diffuse correlation spectroscopy (DCS) flow-oximeter to noninvasively quantify muscle blood flow and oxygenation responses during ES. Ten healthy subjects were tested using the integrated system. The muscle stimulator delivered biphasic electrical current to right leg quadriceps muscle, and a custom-made DCS flow-oximeter was used for simultaneous measurements of muscle blood flow and oxygenation in both legs. To minimize motion artifact of muscle fibers during ES, a novel gating algorithm was developed for data acquisition at the time when the muscle was relaxed. ES at 2, 10, and 50 Hz were applied for 20 min on each subject in three days sequentially. Results demonstrate that the 20-min ES at all frequencies promoted muscle blood flow significantly. However, only the ES at 10 Hz resulted in significant and persistent increases in oxy-hemoglobin concentration during and post ES. This pilot study supports the application of the integrated system to quantify tissue hemodynamic improvements for the optimization of ES treatment in patients suffering from diseases caused by poor blood circulation and low tissue oxygenation (e.g., pressure ulcer).

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Yu Shang ; Yu Lin ; Brad A. Henry ; Ran Cheng ; Chong Huang, et al.
"Noninvasive evaluation of electrical stimulation impacts on muscle hemodynamics via integrating diffuse optical spectroscopies with muscle stimulator", J. Biomed. Opt. 18(10), 105002 (Oct 04, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.105002


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