Research Papers: Imaging

Monte Carlo simulation of light transport in tissue for optimizing light delivery in photoacoustic imaging of the sentinel lymph node

[+] Author Affiliations
Vijitha Periyasamy, Manojit Pramanik

Indian Institute of Science, Electrical Engineering, Biomedical Imaging Laboratory, Bangalore 560012, India

J. Biomed. Opt. 18(10), 106008 (Oct 09, 2013). doi:10.1117/1.JBO.18.10.106008
History: Received May 25, 2013; Revised September 13, 2013; Accepted September 23, 2013
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Abstract.  Noninvasive or minimally invasive identification of sentinel lymph node (SLN) is essential to reduce the surgical effects of SLN biopsy. Photoacoustic (PA) imaging of SLN in animal models has shown its promise for clinical use in the future. Here, we present a Monte Carlo simulation for light transport in the SLN for various light delivery configurations with a clinical ultrasound probe. Our simulation assumes a realistic tissue layer model and also can handle the transmission/reflectance at SLN-tissue boundary due to the mismatch of refractive index. Various light incidence angles show that for deeply situated SLNs the maximum absorption of light in the SLN is for normal incidence. We also show that if a part of the diffused reflected photons is reflected back into the skin using a reflector, the absorption of light in the SLN can be increased significantly to enhance the PA signal.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Vijitha Periyasamy and Manojit Pramanik
"Monte Carlo simulation of light transport in tissue for optimizing light delivery in photoacoustic imaging of the sentinel lymph node", J. Biomed. Opt. 18(10), 106008 (Oct 09, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.106008


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