Research Papers: Sensing

Discrimination of patients with diabetes mellitus and healthy subjects based on laser-induced breakdown spectroscopy of their fingernails

[+] Author Affiliations
Maryam Bahreini, Behnam Ashrafkhani, Seyed Hassan Tavassoli

Shahid Beheshti University, Laser and Plasma Research Institute, G. C., Evin, Tehran 1983963113, Iran

J. Biomed. Opt. 18(10), 107006 (Oct 15, 2013). doi:10.1117/1.JBO.18.10.107006
History: Received July 16, 2013; Revised September 25, 2013; Accepted September 26, 2013
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Abstract.  Laser-induced breakdown spectroscopy (LIBS) is applied to investigate the effect of diabetes mellitus (DM) on the elemental composition of fingernails. Measurements are carried out on 85 fingernail clippings including 51 diabetic and 34 control subjects. An auto-focus system has been designed and used in experiments to improve the repeatability of LIBS measurements. Classification of diabetic and nondiabetic subjects is examined using discriminant function analysis (DFA) method. This classification is based on 82 atomic, ionic, and molecular emission lines belonging to 13 elements as well as one molecule of fingernails. Emission lines that can be used as the best predictors are identified. The possibility of using this method for screening purposes is discussed based on the classification results. This preliminary work shows the ability of LIBS of fingernails in discrimination of DM patients and nondiabetic subjects using DFA method and its feasibility in screening purposes.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Maryam Bahreini ; Behnam Ashrafkhani and Seyed Hassan Tavassoli
"Discrimination of patients with diabetes mellitus and healthy subjects based on laser-induced breakdown spectroscopy of their fingernails", J. Biomed. Opt. 18(10), 107006 (Oct 15, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.107006


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