JBO Letters

Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display

[+] Author Affiliations
Jiawen Li, Zhongping Chen

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612

University of California, Irvine, Beckman Laser Institute, Irvine, California 92612

University of California, Irvine, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Irvine, California 92617

Teng Ma, K. Kirk Shung, Qifa Zhou

University of Southern California, NIH Ultrasonic Transducer Resource Center, Los Angeles, California 90089

Joseph Jing

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612

University of California, Irvine, Beckman Laser Institute, Irvine, California 92612

Jun Zhang

University of California, Irvine, Beckman Laser Institute, Irvine, California 92612

Pranav M. Patel

University of California, Irvine, Division of Cardiology, Irvine, California 92868

University of California, Irvine, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Irvine, California 92617

J. Biomed. Opt. 18(10), 100502 (Oct 21, 2013). doi:10.1117/1.JBO.18.10.100502
History: Received July 24, 2013; Revised September 5, 2013; Accepted September 16, 2013
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Abstract.  We have developed a novel miniature integrated optical coherence tomography (OCT)-intravascular ultrasound (IVUS) probe, with a 1.5-mm-long rigid part and 0.9-mm outer diameter, for real-time intracoronary imaging of atherosclerotic plaques and guiding of interventional procedures. By placing the OCT ball lens and IVUS transducer back-to-back at the same axial position, this probe can provide automatically coregistered, coaxial OCT-IVUS imaging. To demonstrate its real-time capability, three-dimensional OCT-IVUS imaging of a pig’s coronary artery displaying in polar coordinates, as well as images of three major types of atherosclerotic plaques in human cadaver coronary segments, were obtained using this probe and our upgraded system. Histology validation is also presented.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Jiawen Li ; Teng Ma ; Joseph Jing ; Jun Zhang ; Pranav M. Patel, et al.
"Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display", J. Biomed. Opt. 18(10), 100502 (Oct 21, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.100502


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