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Research Papers: Sensing

Determination of optical properties by interstitial white light spectroscopy using a custom fiber optic probe

[+] Author Affiliations
Timothy M. Baran

University of Rochester Medical Center, Department of Imaging Sciences, Rochester, New York 14642

Michael C. Fenn

University of Rochester, Department of Physics & Astronomy, Rochester, New York 14627

Thomas H. Foster

University of Rochester Medical Center, Department of Imaging Sciences, Rochester, New York 14642

University of Rochester, Department of Physics & Astronomy, Rochester, New York 14627

J. Biomed. Opt. 18(10), 107007 (Oct 22, 2013). doi:10.1117/1.JBO.18.10.107007
History: Received July 2, 2013; Revised September 23, 2013; Accepted September 24, 2013
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Abstract.  We demonstrate interstitial recovery of absorption and scattering coefficients using a custom optical probe and a Monte Carlo (MC)–based recovery algorithm. The probe consists of six side-firing spectroscopy fibers contained in a 1.1-mm outer diameter cladding, with each fiber having a different axial and angular position on the probe. Broadband white light is delivered by one of the fibers and is detected steady-state by the remaining fibers. These spatially and spectrally resolved data are analyzed using a MC-based fitting algorithm in order to extract the local optical properties. The technique was verified in tissue-simulating phantoms consisting of Intralipid-20% as a scatterer and either manganese meso-tetra (4-sulfanatophenyl) porphine or intact human erythrocytes as an absorber. Absorption coefficients were recovered with a mean error of 9% and scattering coefficients were recovered with a mean error of 19%, whereas the hemoglobin oxygen saturation was recovered with a mean error of 12%. These results demonstrate the feasibility of optical property recovery for situations in which surface-contact spectroscopy is not a possibility, and where only a single probe can be inserted into the tissue.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Timothy M. Baran ; Michael C. Fenn and Thomas H. Foster
"Determination of optical properties by interstitial white light spectroscopy using a custom fiber optic probe", J. Biomed. Opt. 18(10), 107007 (Oct 22, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.107007


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