Research Papers: Sensing

Substantiation of medical and technical requirements for noninvasive spectrophotometric diagnostic devices

[+] Author Affiliations
Andrey V. Dunaev

University of Dundee, Photonics and Nanoscience Group, School of Engineering, Physics and Mathematics, Dundee DD1 4HN, United Kingdom

State University—Education-Science-Production Complex, Scientific-Educational Center of Biomedical Engineering, Oryol 302020, Russian Federation

Evgeny A. Zherebtsov

State University—Education-Science-Production Complex, Scientific-Educational Center of Biomedical Engineering, Oryol 302020, Russian Federation

Dmitrii A. Rogatkin

Moscow Regional Research and Clinical Institute “MONIKI,” Laboratory of Medical & Physics Research, Moscow 12911, Russian Federation

Neil A. Stewart, Sergei G. Sokolovski, Edik U. Rafailov

University of Dundee, Photonics and Nanoscience Group, School of Engineering, Physics and Mathematics, Dundee DD1 4HN, United Kingdom

J. Biomed. Opt. 18(10), 107009 (Oct 28, 2013). doi:10.1117/1.JBO.18.10.107009
History: Received May 13, 2013; Revised September 13, 2013; Accepted October 1, 2013
Text Size: A A A

Abstract.  A scientific approach to the formulation of medical and technical requirements (MTRs) for noninvasive spectrophotometric diagnostic devices using optical technologies such as laser Doppler flowmetry and absorption spectroscopy is proposed. The theoretical modeling framework, metrological certification, and testing of these devices are still in the early stages of development. The theoretical estimation of the received signal levels for wavelengths between 514 and 940 nm is highly dependent on the blood volume level in the subject tissue. The proposed approach allows, in particular, the calculation of technical and metrological performance constraints of the instruments, such as the ranges of the sensitivity and power-related signal-to-noise ratios for different spectral channels and different biomedical (biochemical and physiological) parameters. Substantiation of specialized MTRs for the noninvasive spectrophotometric diagnostic devices can enable them to develop to the level of standardized measurement techniques.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Andrey V. Dunaev ; Evgeny A. Zherebtsov ; Dmitrii A. Rogatkin ; Neil A. Stewart ; Sergei G. Sokolovski, et al.
"Substantiation of medical and technical requirements for noninvasive spectrophotometric diagnostic devices", J. Biomed. Opt. 18(10), 107009 (Oct 28, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.107009


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.