Special Section on Optical Coherence Tomography and Interferometry: Advanced Engineering and Biomedical Applications

Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking

[+] Author Affiliations
Peijun Gong, Robert A. McLaughlin

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical + Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Yih Miin Liew

University of Malaya, Department of Biomedical Engineering, Faculty of Engineering, Kuala Lumpur 50603, Malaysia

Peter R. T. Munro, David D. Sampson

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical + Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

The University of Western Australia, Centre for Microscopy, Characterisation and Analysis, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Fiona M. Wood

Royal Perth Hospital, Burns Service of Western Australia, Wellington Street, Perth, Western Australia 6000, Australia

The University of Western Australia, School of Surgery, Burn Injury Research Unit, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

J. Biomed. Opt. 19(2), 021111 (Nov 05, 2013). doi:10.1117/1.JBO.19.2.021111
History: Received June 28, 2013; Revised September 19, 2013; Accepted September 20, 2013
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Abstract.  The formation of burn-scar tissue in human skin profoundly alters, among other things, the structure of the dermis. We present a method to characterize dermal scar tissue by the measurement of the near-infrared attenuation coefficient using optical coherence tomography (OCT). To generate accurate en face parametric images of attenuation, we found it critical to first identify (using speckle decorrelation) and mask the tissue vasculature from the three-dimensional OCT data. The resulting attenuation coefficients in the vasculature-masked regions of the dermis of human burn-scar patients are lower in hypertrophic (3.8±0.4mm1) and normotrophic (4.2±0.9mm1) scars than in contralateral or adjacent normal skin (6.3±0.5mm1). Our results suggest that the attenuation coefficient of vasculature-masked tissue could be used as an objective means to assess human burn scars.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Peijun Gong ; Robert A. McLaughlin ; Yih Miin Liew ; Peter R. T. Munro ; Fiona M. Wood, et al.
"Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking", J. Biomed. Opt. 19(2), 021111 (Nov 05, 2013). ; http://dx.doi.org/10.1117/1.JBO.19.2.021111


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