Research Papers: Therapeutic

Parameters affecting ultrafast laser microsurgery of subepithelial voids for scar treatment in vocal folds

[+] Author Affiliations
Murat Yildirim, Onur Ferhanoglu, Adela Ben-Yakar

University of Texas at Austin, Department of Mechanical Engineering, Austin, Texas 78712

James Kobler, Steven M. Zeitels

Massachusetts General Hospital, Center for Laryngeal Surgery and Voice Rehabilitation, Boston, Massachusetts 02114

J. Biomed. Opt. 18(11), 118001 (Nov 05, 2013). doi:10.1117/1.JBO.18.11.118001
History: Received March 20, 2013; Revised August 27, 2013; Accepted October 1, 2013
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Abstract.  Toward developing a new method for restoring tissue viscoelasticity in scarred vocal folds, we previously proposed a method to localize biomaterials within subepithelial voids ablated using ultrafast laser pulses. The clinical implementation of this method necessitates the quantification of the laser parameters for ablating scarred tissue. Here, we present a comprehensive study of these parameters including ablation threshold and bubble lifetime in healthy and scarred tissues. We also present a new method for extracting tissue-specific ablation threshold and scattering lengths of different tissue layers. This method involves finding the ablation threshold at multiple depths and solving the equations based on Beer’s law of light attenuation for each depth to estimate the unknown parameters. Measured threshold fluences were 1.75J/cm2 for vocal folds and 0.5J/cm2 for cheek pouches for 3-ps, 776-nm laser pulses. Scarred pouches exhibited 30% lower threshold than healthy pouches, possibly due to the degraded mechanical properties of scarred collagen during wound healing. The analysis of tissue architecture indicated a direct correlation between the ablation threshold and tissue tensile strength and that the bubble lifetime is inversely related to tissue stiffness. Overall, this study sheds light on the required laser parameters for successful implementation of ultrafast laser ablation for phonosurgery.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Topics

Tissues ; Lasers

Citation

Murat Yildirim ; Onur Ferhanoglu ; James Kobler ; Steven M. Zeitels and Adela Ben-Yakar
"Parameters affecting ultrafast laser microsurgery of subepithelial voids for scar treatment in vocal folds", J. Biomed. Opt. 18(11), 118001 (Nov 05, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.11.118001


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