Research Papers: Sensing

Ultrasound-heated photoacoustic flowmetry

[+] Author Affiliations
Lidai Wang, Junjie Yao, Konstantin I. Maslov, Wenxin Xing, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899

J. Biomed. Opt. 18(11), 117003 (Nov 05, 2013). doi:10.1117/1.JBO.18.11.117003
History: Received March 8, 2013; Revised October 6, 2013; Accepted October 10, 2013
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Abstract.  We report the development of photoacoustic flowmetry assisted by high-intensity focused ultrasound (HIFU). This novel method employs HIFU to generate a heating impulse in the flow medium, followed by photoacoustic monitoring of the thermal decay process. Photoacoustic flowmetry in a continuous medium remains a challenge in the optical diffusive regime. Here, both the HIFU heating and photoacoustic detection can focus at depths beyond the optical diffusion limit (1mm in soft tissue). This method can be applied to a continuous medium, i.e., a medium without discrete scatterers or absorbers resolvable by photoacoustic imaging. Flow speeds up to 41mm·s1 have been experimentally measured in a blood phantom covered by 1.5-mm-thick tissue.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Lidai Wang ; Junjie Yao ; Konstantin I. Maslov ; Wenxin Xing and Lihong V. Wang
"Ultrasound-heated photoacoustic flowmetry", J. Biomed. Opt. 18(11), 117003 (Nov 05, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.11.117003


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