Research Papers: General

Luminescence investigation of photosensitizer distribution in skin: correlation of singlet oxygen kinetics with the microarchitecture of the epidermis

[+] Author Affiliations
Jan C. Schlothauer, Julian Falckenhayn, Tobias Perna, Steffen Hackbarth, Beate Röder

Humboldt-Universität zu Berlin, Unter den Linden 6, 10099 Berlin, Germany

J. Biomed. Opt. 18(11), 115001 (Nov 05, 2013). doi:10.1117/1.JBO.18.11.115001
History: Received August 15, 2013; Revised October 11, 2013; Accepted October 14, 2013
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Abstract.  This is the first study showing that singlet oxygen kinetics of topically applied photosensitizers coincides with the microarchitecture of skin, e.g., fissures and hair follicles. The kinetics indicate a chemical interaction of singlet oxygen with the skin, which allows differentiating between residual crème, e.g., in the follicular orifice, and photosensitizer penetrated into the skin. We show the feasibility of an easy-to-use fiber optic application providing the opportunity for in situ investigation, as well as a setup with focused optics for high-resolution two-dimensional scanning of singlet oxygen luminescence kinetics in skin samples. The results show that time-resolved singlet oxygen luminescence detection in tissue is a desirable tool for medical therapy, diagnostics, and evaluation of singlet oxygen interaction with biological environments.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Topics

Luminescence ; Oxygen ; Skin

Citation

Jan C. Schlothauer ; Julian Falckenhayn ; Tobias Perna ; Steffen Hackbarth and Beate Röder
"Luminescence investigation of photosensitizer distribution in skin: correlation of singlet oxygen kinetics with the microarchitecture of the epidermis", J. Biomed. Opt. 18(11), 115001 (Nov 05, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.11.115001


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