Special Section on Advanced Biomedical Imaging and Sensing

Fluorescent ZnCdS nanoparticles for glucose sensing

[+] Author Affiliations
Vyacheslav I. Kochubey, Elena K. Volkova

Saratov State University, Chair of Optics and Biophotonics, 83, Astrakhanskaya Street, Saratov 410012, Russia

Julia G. Konyukhova

Saratov State University, Institute of Mechanics and Physics, B. Kazachaya Street, 112a, Saratov 410012, Russia

J. Biomed. Opt. 19(1), 011020 (Nov 05, 2013). doi:10.1117/1.JBO.19.1.011020
History: Received April 1, 2013; Revised October 11, 2013; Accepted October 14, 2013
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Abstract.  The effect of glucose on fluorescence of synthesized ZnCdS nanoparticles in the presence of glucose oxidase or in a mixture of glucose oxidase and peroxidase has been investigated. Behavior of fluorescence characteristics of ZnCdS nanoparticles with nonstabilized surface and coated with polymer shell is compared. It has been shown that, for uncoated ZnCdS nanoparticles, hydrogen peroxide formed by glucose oxidation with glucose oxidase causes static quenching of the nanoparticle fluorescence. A quenching mechanism is proposed in which surface centers of fluorescence, which include cationic vacancies, trap oxygen ions supplied by hydrogen peroxide. It has been shown that the linear Stern–Volmer plot has no threshold within the investigated concentrations of glucose. The sensitivity of ZnCdS nanoparticles to glucose, determined from the slope of linear Stern–Volmer plot, is maximum for polymer-coated nanoparticles and is 12.2ml/mg. With peroxidase, there is a threshold concentration of glucose (160 μM) below which the nanoparticles become insensitive to glucose.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Vyacheslav I. Kochubey ; Elena K. Volkova and Julia G. Konyukhova
"Fluorescent ZnCdS nanoparticles for glucose sensing", J. Biomed. Opt. 19(1), 011020 (Nov 05, 2013). ; http://dx.doi.org/10.1117/1.JBO.19.1.011020


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