Special Section on Optical Elastography and Measurement of Tissue Biomechanics

Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography

[+] Author Affiliations
Shaozhen Song

University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195

University of Dundee, School of Engineering, Physics and Mathematics, Dundee DD1 4HN, Scotland, UK

Zhihong Huang

University of Dundee, School of Engineering, Physics and Mathematics, Dundee DD1 4HN, Scotland, UK

Thu-Mai Nguyen, Emily Y. Wong, Bastien Arnal, Matthew O’Donnell

University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195

Ruikang K. Wang

University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195

University of Washington, Department of Ophthalmology, 325 9th Avenue, Seattle, Washington 98104

J. Biomed. Opt. 18(12), 121509 (Nov 08, 2013). doi:10.1117/1.JBO.18.12.121509
History: Received June 3, 2013; Revised October 15, 2013; Accepted October 17, 2013
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Abstract.  We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of 47kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Shaozhen Song ; Zhihong Huang ; Thu-Mai Nguyen ; Emily Y. Wong ; Bastien Arnal, et al.
"Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography", J. Biomed. Opt. 18(12), 121509 (Nov 08, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.12.121509


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