Research Papers: Sensing

Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli

[+] Author Affiliations
Martial H. Geiser, Frederic Truffer, Hugo Evequoz

University of Applied Sciences Western Switzerland, Institute of Systems Engineering, Sion 1950, Switzerland

Hafid Khayi, Benjamin Mottet, Christophe Chiquet

Joseph Fourier University, Grenoble University Hospital, Department of Ophthalmology, Grenoble 38043, France

J. Biomed. Opt. 18(12), 127001 (Dec 02, 2013). doi:10.1117/1.JBO.18.12.127001
History: Received March 29, 2013; Revised October 29, 2013; Accepted October 30, 2013
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Abstract.  We describe a device to measure blood perfusion for the human optic nerve head (ONH) based on laser Doppler flowmetry (LDF) with a flicker stimuli of the fovea region. This device is self-aligned for LDF measurements and includes near-infrared pupil observation, green illumination, and observation of the ONH. The optical system of the flowmeter is based on a Schlieren arrangement which collects only photons that encounter multiple scattering and are back-scattered out of the illumination point. LDF measurements are based on heterodyne detection of Doppler shifted back-scattered light. We also describe an automated analysis of the LDF signals which rejects artifacts and false signals such as blinks. By using a Doppler simulator consisting of a lens and a rotating diffusing wheel, we demonstrate that velocity and flow vary linearly with the speed of the wheel. A cohort of 12 healthy subjects demonstrated that flicker stimulation induces an increase of 17.8% of blood flow in the ONH.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Martial H. Geiser ; Frederic Truffer ; Hugo Evequoz ; Hafid Khayi ; Benjamin Mottet, et al.
"Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli", J. Biomed. Opt. 18(12), 127001 (Dec 02, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.12.127001


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