Research Papers: Therapeutic

Influence of different energy densities of laser phototherapy on oral wound healing

[+] Author Affiliations
Vivian Petersen Wagner, Marco Antonio Trevizani Martins, Chris Krebs Danilevicz, Alessandra Selinger Magnusson, Manoel Sant’Ana Filho, Manoela Domingues Martins

Universidade Federal do Rio Grande do Sul, School of Dentistry, Department of Oral Pathology, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil

Luise Meurer

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Department of Pathology, Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Márcia Martins Marques

Universidade de São Paulo, School of Dentistry, Department of Dentistry, São Paulo, 05508-000 Brazil

Cristiane Helena Squarize

University of Michigan School of Dentistry, Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, Ann Arbor, Michigan 48109-1078

J. Biomed. Opt. 18(12), 128002 (Dec 10, 2013). doi:10.1117/1.JBO.18.12.128002
History: Received August 28, 2013; Revised October 4, 2013; Accepted November 5, 2013
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Abstract.  The aim of the present prospective study was to evaluate the impact of laser phototherapy (LPT) on the healing of oral ulcers. Different power densities were used on oral wounds in Wistar rats (n=72) randomly divided into three groups: control (0J/cm2), 4J/cm2 laser, and 20J/cm2 laser. Ulcers (3 mm in diameter) were made on the dorsum of the tongue with a punch. Irradiation with an indium-gallium-aluminum-phosphide laser (660 nm; output power: 40 mW; spot size: 0.04cm2) was performed once a day in close contact with the ulcer for 14 consecutive days. A statistically significant acceleration in healing time was found with wounds treated with 4J/cm2 LPT. Moreover, striking differences were found in the ulcer area, healing percentage, degree of reepithelialization, and collagen deposition. The most significant changes occurred after 5 days of irradiation. Based on the conditions employed in the present study, LPT is capable of accelerating the oral mucosa wound-healing process. Moreover, faster and more organized reepithelialization and tissue healing of the oral mucosa were achieved with an energy density of 4J/cm2 in comparison to 20J/cm2.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Vivian Petersen Wagner ; Luise Meurer ; Marco Antonio Trevizani Martins ; Chris Krebs Danilevicz ; Alessandra Selinger Magnusson, et al.
"Influence of different energy densities of laser phototherapy on oral wound healing", J. Biomed. Opt. 18(12), 128002 (Dec 10, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.12.128002


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