Special Section on Optical Elastography and Measurement of Tissue Biomechanics

From supersonic shear wave imaging to full-field optical coherence shear wave elastography

[+] Author Affiliations
Amir Nahas

Institut Langevin, ESPCI-ParisTech, CNRS UMR7587, INSERM U979, 1 rue Jussieu, Paris 75005, France

Mickaël Tanter

Institut Langevin, ESPCI-ParisTech, CNRS UMR7587, INSERM U979, 1 rue Jussieu, Paris 75005, France

Thu-Mai Nguyen

Institut Langevin, ESPCI-ParisTech, CNRS UMR7587, INSERM U979, 1 rue Jussieu, Paris 75005, France

Jean-Marie Chassot

Institut Langevin, ESPCI-ParisTech, CNRS UMR7587, INSERM U979, 1 rue Jussieu, Paris 75005, France

Mathias Fink

Institut Langevin, ESPCI-ParisTech, CNRS UMR7587, INSERM U979, 1 rue Jussieu, Paris 75005, France

A. Claude Boccara

Institut Langevin, ESPCI-ParisTech, CNRS UMR7587, INSERM U979, 1 rue Jussieu, Paris 75005, France

J. Biomed. Opt. 18(12), 121514 (Dec 19, 2013). doi:10.1117/1.JBO.18.12.121514
History: Received July 1, 2013; Revised November 27, 2013; Accepted December 2, 2013
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Abstract.  Elasticity maps of tissue have proved to be particularly useful in providing complementary contrast to ultrasonic imaging, e.g., for cancer diagnosis at the millimeter scale. Optical coherence tomography (OCT) offers an endogenous contrast based on singly backscattered optical waves. Adding complementary contrast to OCT images by recording elasticity maps could also be valuable in improving OCT-based diagnosis at the microscopic scale. Static elastography has been successfully coupled with full-field OCT (FF-OCT) in order to realize both micrometer-scale sectioning and elasticity maps. Nevertheless, static elastography presents a number of drawbacks, mainly when stiffness quantification is required. Here, we describe the combination of two methods: transient elastography, based on speed measurements of shear waves induced by ultrasonic radiation forces, and FF-OCT, an en face OCT approach using an incoherent light source. The use of an ultrafast ultrasonic scanner and an ultrafast camera working at 10,000 to 30,000images/s made it possible to follow shear wave propagation with both modalities. As expected, FF-OCT is found to be much more sensitive than ultrafast ultrasound to tiny shear vibrations (a few nanometers and micrometers, respectively). Stiffness assessed in gel phantoms and an ex vivo rat brain by FF-OCT is found to be in good agreement with ultrasound shear wave elastography.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Amir Nahas ; Mickaël Tanter ; Thu-Mai Nguyen ; Jean-Marie Chassot ; Mathias Fink, et al.
"From supersonic shear wave imaging to full-field optical coherence shear wave elastography", J. Biomed. Opt. 18(12), 121514 (Dec 19, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.12.121514


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