Special Section on Optical Elastography and Measurement of Tissue Biomechanics

Viscosity measurement based on shear-wave laser speckle contrast analysis

[+] Author Affiliations
Yi Cheng

Imperial College London, Department of Bioengineering, London, SW7 2AZ, United Kingdom

Sinan Li

Imperial College London, Department of Bioengineering, London, SW7 2AZ, United Kingdom

Robert J. Eckersley

King’s College London, Department of Biomedical Engineering, London, SE1 7EH, United Kingdom

Daniel S. Elson

Imperial College London, Hamlyn Centre for Robotic Surgery, Department of Surgery and Cancer, London, SW7 2AZ, United Kingdom

Meng-Xing Tang

Imperial College London, Department of Bioengineering, London, SW7 2AZ, United Kingdom

J. Biomed. Opt. 18(12), 121511 (Dec 19, 2013). doi:10.1117/1.JBO.18.12.121511
History: Received July 20, 2013; Revised November 19, 2013; Accepted November 27, 2013
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Abstract.  Tissue viscosity is correlated with tissue pathological changes and provides information for tissue characterization. In this study, we report an optical method to track continuous shear-wave propagation at centimeter depths in an optically turbid medium. Shear-wave attenuation coefficients were measured at multiple frequencies using shear-wave laser speckle contrast analysis (SW-LASCA) to quantitatively estimate tissue viscosity using the Voigt model. Shear waves were generated within tissue-mimicking phantoms by an amplitude-modulated ultrasound (modulation frequency: 100 to 600 Hz) and tracked by time-resolved laser speckle contrast difference received on a charged-coupled device camera. Averaged contrast difference over a selected time window was related to shear-wave amplitude and used to calculate the shear-wave attenuation coefficient. Phantoms of varying viscosities (0.1 and 0.3 Pa s) were studied. Attenuation coefficients for different shear-wave frequencies (100 to 600 Hz) were calculated. Derived viscosity values had a maximum standard deviation of 9%, and these values were consistent with the independent measurements reported in a previous study using nonoptical methods.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Yi Cheng ; Sinan Li ; Robert J. Eckersley ; Daniel S. Elson and Meng-Xing Tang
"Viscosity measurement based on shear-wave laser speckle contrast analysis", J. Biomed. Opt. 18(12), 121511 (Dec 19, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.12.121511


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