Special Section on Optical Elastography and Measurement of Tissue Biomechanics

Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues

[+] Author Affiliations
Kelsey M. Kennedy, Robert A. McLaughlin, Brendan F. Kennedy

University of Western Australia, School of Electrical, Electronic & Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Alan Tien, Christobel M. Saunders

University of Western Australia, School of Surgery, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Bruce Latham

PathWest, 197 Wellington Street, Perth, Western Australia 6000, Australia

David D. Sampson

University of Western Australia, School of Electrical, Electronic & Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

University of Western Australia, Centre for Microscopy, Characterisation & Analysis, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

J. Biomed. Opt. 18(12), 121510 (Dec 23, 2013). doi:10.1117/1.JBO.18.12.121510
History: Received July 2, 2013; Revised November 15, 2013; Accepted November 20, 2013
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Abstract.  Optical coherence elastography (OCE) is an emerging imaging technique that probes microscale mechanical contrast in tissues with the potential to differentiate healthy and malignant tissues. However, conventional OCE techniques are limited to imaging the first 1 to 2 mm of tissue in depth. We demonstrate, for the first time, OCE measurements deep within human tissues using needle OCE, extending the potential of OCE as a surgical guidance tool. We use needle OCE to detect tissue interfaces based on mechanical contrast in both normal and malignant breast tissues in freshly excised human mastectomy samples, as validated against histopathology. Further, we demonstrate the feasibility of in situ measurements >4cm from the tissue surface using ultrasound guidance of the OCE needle probe. With further refinement, our method may potentially aid in accurate detection of the boundary of the tumor to help ensure full removal of all malignant tissues, which is critical to the success of breast-conserving surgery.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Kelsey M. Kennedy ; Robert A. McLaughlin ; Brendan F. Kennedy ; Alan Tien ; Bruce Latham, et al.
"Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues", J. Biomed. Opt. 18(12), 121510 (Dec 23, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.12.121510


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