Research Papers: General

Spatial frequency analysis of high-density lipoprotein and iron-oxide nanoparticle transmission electron microscope image structure for pattern recognition in heterogeneous fields

[+] Author Affiliations
Stewart Russell

City College of New York, Mechanical Engineering Department, New York, New York 10031

Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755

Thien An Nguyen

City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Physics Department, New York, New York 10031

Clyde Rey Torres

City College of New York, Mechanical Engineering Department, New York, New York 10031

Stephen Bhagroo

City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Physics Department, New York, New York 10031

Milo J. Russell

City College of New York, Chemistry Department, New York, New York 10031

Robert R. Alfano

City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Physics Department, New York, New York 10031

J. Biomed. Opt. 19(1), 015004 (Jan 03, 2014). doi:10.1117/1.JBO.19.1.015004
History: Received August 20, 2013; Revised November 12, 2013; Accepted November 25, 2013
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Abstract.  The optical spatial frequencies of tumor interstitial fluid (TIF) are investigated. As a concentrated colloidal suspension of interacting native nanoparticles, the TIF can develop internal ordering under shear stress that may hinder delivery of antitumor agents within tumors. A systematic method is presented to characterize the TIF nanometer-scale microstructure in a model suspension of superparamagnetic iron-oxide nanoparticles and reconstituted high-density lipoprotein by Fourier spatial frequency (FSF) analysis so as to differentiate between jammed and fluid structural features in static transmission electron microscope images. The FSF method addresses one obstacle faced in achieving quantitative dosimetry to neoplastic tissue, that of detecting these nanoscale barriers to transport, such as would occur in the extravascular space immediately surrounding target cells.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Stewart Russell ; Thien An Nguyen ; Clyde Rey Torres ; Stephen Bhagroo ; Milo J. Russell, et al.
"Spatial frequency analysis of high-density lipoprotein and iron-oxide nanoparticle transmission electron microscope image structure for pattern recognition in heterogeneous fields", J. Biomed. Opt. 19(1), 015004 (Jan 03, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.1.015004


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