Research Papers: Imaging

Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging

[+] Author Affiliations
Mansik Jeon

Pohang University of Science and Technology, Departments of Electrical Engineering and Creative IT Engineering, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 790-784, Republic of Korea

Wentao Song, Jonathan F. Lovell

State University of New York, The University at Buffalo, Department of Biomedical Engineering, Buffalo, New York 14260

Elizabeth Huynh, Brandon L. Helfield, Gang Zheng

University of Toronto, Department of Medical Biophysics, Toronto M5S 1A1, Canada

Jungho Kim, Jungtaek Oh

Samsung Medison, Seoul, 135-851, Republic of Korea

Jeesu Kim

Pohang University of Science and Technology, Departments of Electrical Engineering and Creative IT Engineering, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 790-784, Republic of Korea

Ben Y. C. Leung

Sunnybrook Health Sciences Center, Toronto M5S 1A1, Canada

David E. Goertz

University of Toronto, Department of Medical Biophysics, Toronto M5S 1A1, Canada

Sunnybrook Health Sciences Center, Toronto M5S 1A1, Canada

Chulhong Kim

Pohang University of Science and Technology, Departments of Electrical Engineering and Creative IT Engineering, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 790-784, Republic of Korea

J. Biomed. Opt. 19(1), 016005 (Jan 06, 2014). doi:10.1117/1.JBO.19.1.016005
History: Received October 16, 2013; Revised December 4, 2013; Accepted December 6, 2013
Text Size: A A A

Abstract.  Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Increasingly, photoacoustic and ultrasound have been integrated in terms of hardware instrumentation. To generate a broadly accessible dual-modality contrast agent, we generated microbubbles (a standard ultrasound contrast agent) in a solution of methylene blue (a standard photoacoustic dye). This MB2 solution was formed effectively and was optimized as a dual-modality contrast solution. As microbubble concentration increased (with methylene blue concentration constant), photoacoustic signal was attenuated in the MB2 solution. When methylene blue concentration increased (with microbubble concentration held constant), no ultrasonic interference was observed. Using an MB2 solution that strongly attenuated all photoacoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (>800-fold increase), providing a new method for spatiotemporal control of photoacoustic signal generation.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Mansik Jeon ; Wentao Song ; Elizabeth Huynh ; Jungho Kim ; Jeesu Kim, et al.
"Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging", J. Biomed. Opt. 19(1), 016005 (Jan 06, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.1.016005


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.