Research Papers: General

Deep-tissue light delivery via optrode arrays

[+] Author Affiliations
Tanya V.F. Abaya, Mohit Diwekar, Prashant Tathireddy, Loren Rieth

University of Utah, Department of Electrical and Computer Engineering, 36 Wasatch Dr., Salt Lake City, Utah 84112

Steve Blair, Florian Solzbacher

University of Utah, Department of Electrical and Computer Engineering, 36 Wasatch Dr., Salt Lake City, Utah 84112

University of Utah, Department of Bioengineering, 50 S Central Campus Dr., Salt Lake City, Utah 84112

J. Biomed. Opt. 19(1), 015006 (Jan 09, 2014). doi:10.1117/1.JBO.19.1.015006
History: Received July 21, 2013; Revised December 17, 2013; Accepted December 17, 2013
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Abstract.  We establish performance characteristics of needle-type waveguides in three-dimensional array architectures as light delivery interfaces into deep tissue for applications, such as optogenetic and infrared (IR) neural stimulation. A single optrode waveguide achieves as high as 90% transmission efficiency, even at tissue depths >1mm. Throughout the visible and near-IR spectrum, the effective light attenuation through the waveguide is 3 orders of magnitude smaller than attenuation in tissue/water, as confirmed by both simulation and experimental results. Light emission profiles from the optrode tips into tissue were also measured. Beam widths of 70 to 150 μm and full-angle divergence ranging from 13 to 40 deg in tissue can be achieved. These beam characteristics satisfy a wide range of requirements for targeted illumination in neural stimulation.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Tanya V.F. Abaya ; Mohit Diwekar ; Steve Blair ; Prashant Tathireddy ; Loren Rieth, et al.
"Deep-tissue light delivery via optrode arrays", J. Biomed. Opt. 19(1), 015006 (Jan 09, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.1.015006


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