Elastography is a recently developed field to evaluate the biomechanical properties of soft tissue for medical diagnosis. Stiffness variations have indeed proven to be good indicators of pathological state, providing valuable additional information to structural images in many applications: breast tumor detection,1 liver fibrosis diagnosis,2,3 and vascular pathologies characterization.4,5 Several techniques have been developed in the past 20 years, most of them involving magnetic resonance imaging (MRI)6 or ultrasound7,8 modalities. More recently, optical coherence elastography (OCE) has emerged9 based on the optical coherence tomography (OCT) imaging. OCT provides high spatial resolution (micron scale) and is, therefore, an ideal technology to examine small organs such as skin layers, ocular tissues (cornea, intraocular lens), and peripheral vessels. The earliest OCE techniques used imaging of tissue displacements following a static deformation.10,11 Static elastography, however, suffers from the following limitations: operator dependence (variability of the applied deformation) and nonquantitative estimates of the stiffness due to high sensitivity to boundary conditions (uneven stress distribution).