Research Papers: Sensing

New method for remote and repeatable monitoring of intraocular pressure variations

[+] Author Affiliations
Israel Margalit, Yevgeny Beiderman, Zeev Zalevsky

Bar-Ilan University, Faculty of Engineering, Ramat-Gan 52900, Israel

Alon Skaat, Elkanah Rosenfeld, Michael Belkin

Tel-Aviv University, Goldshleger Eye Research Institute, Tel-Hashomer 52621, Israel

Ralf-Peter Tornow

Augenklini, Schwabachanlage 6, 91054 Erlangen, Germany

Vicente Mico, Javier Garcia

Universitat de València, Facultat de Física, Departamento de Óptica, C/Doctor Moliner 50, 46100 Burjassot, Spain

J. Biomed. Opt. 19(2), 027002 (Feb 06, 2014). doi:10.1117/1.JBO.19.2.027002
History: Received November 11, 2013; Revised January 3, 2014; Accepted January 3, 2014
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Abstract.  We present initial steps toward a new measurement device enabling high-precision, noncontact remote and repeatable monitoring of intraocular pressure (IOP)-based on an innovative measurement principle. Using only a camera and a laser source, the device measures IOP by tracking the secondary speckle pattern trajectories produced by the reflection of an illuminating laser beam from the iris or the sclera. The device was tested on rabbit eyes using two different methods to modify IOP: via an infusion bag and via mechanical pressure. In both cases, the eyes were stimulated with increasing and decreasing ramps of the IOP. As IOP variations changed the speckle distributions reflected back from the eye, data were recorded under various optical configurations to define and optimize the best experimental configuration for the IOP extraction. The association between the data provided by our proposed device and that resulting from controlled modification of the IOP was assessed, revealing high correlation (R2=0.98) and sensitivity and providing a high-precision measurement (5% estimated error) for the best experimental configuration. Future steps will be directed toward applying the proposed measurement principle in clinical trials for monitoring IOP with human subjects.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Israel Margalit ; Yevgeny Beiderman ; Alon Skaat ; Elkanah Rosenfeld ; Michael Belkin, et al.
"New method for remote and repeatable monitoring of intraocular pressure variations", J. Biomed. Opt. 19(2), 027002 (Feb 06, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.2.027002


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