Research Papers: Imaging

Photoacoustic thermography of tissue

[+] Author Affiliations
Haixin Ke, Stephen Tai, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri 63130

J. Biomed. Opt. 19(2), 026003 (Feb 12, 2014). doi:10.1117/1.JBO.19.2.026003
History: Received November 6, 2013; Revised December 28, 2013; Accepted December 31, 2013
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Abstract.  Photoacoustic (PA) techniques can measure temperature in biological tissues because PA signal amplitude is sensitive to tissue temperature. So far, temperature-measuring PA techniques have focused on sensing of temperature changes at a single position. In this work, we photoacoustically measured spatial distribution of temperature in deep tissue. By monitoring the temperature at a single position using a thermocouple, the relationship between the PA signal amplitude and the actual temperature was determined. The relationship was then used to translate a PA image into a temperature map. This study showed that it is possible to calibrate the system for the temperature range of hyperthermia using single-point measurements over a smaller temperature range. Our experimental results showed a precision of 0.8±0.4°C (mean±standard error) in temperature measurement, and a spatial resolution as fine as 1.0 mm. PA techniques can be potentially applied to monitor temperature distribution deep in tissue during hyperthermia treatment of cancer.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Haixin Ke ; Stephen Tai and Lihong V. Wang
"Photoacoustic thermography of tissue", J. Biomed. Opt. 19(2), 026003 (Feb 12, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.2.026003


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