Research Papers: Imaging

Extension of the GATE Monte-Carlo simulation package to model bioluminescence and fluorescence imaging

[+] Author Affiliations
Vesna Cuplov, Sébastien Jan

Service Hospitalier Frédéric Joliot, Commissariat à l’Energie Atomique, 91401 Orsay, France

Iréne Buvat, Frédéric Pain

Laboratoire Imagerie et Modélisation en Neurobiologie et Cancérologie, UMR 8165 CNRS—Université Paris 7—Université Paris 11, France

J. Biomed. Opt. 19(2), 026004 (Feb 12, 2014). doi:10.1117/1.JBO.19.2.026004
History: Received October 16, 2013; Revised January 5, 2014; Accepted January 7, 2014
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Abstract.  The Geant4 Application for Emission Tomography (GATE) is an advanced open-source software dedicated to Monte-Carlo (MC) simulations in medical imaging involving photon transportation (Positron emission tomography, single photon emission computed tomography, computed tomography) and in particle therapy. In this work, we extend the GATE to support simulations of optical imaging, such as bioluminescence or fluorescence imaging, and validate it against the MC for multilayered media standard simulation tool for biomedical optics in simple geometries. A full simulation set-up for molecular optical imaging (bioluminescence and fluorescence) is implemented in GATE, and images of the light distribution emitted from a phantom demonstrate the relevance of using GATE for optical imaging simulations.

© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Vesna Cuplov ; Iréne Buvat ; Frédéric Pain and Sébastien Jan
"Extension of the GATE Monte-Carlo simulation package to model bioluminescence and fluorescence imaging", J. Biomed. Opt. 19(2), 026004 (Feb 12, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.2.026004


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