Research Papers: Imaging

Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study

[+] Author Affiliations
Michele L. Pierro, Jana M. Kainerstorfer, Angelo Sassaroli, Bertan Hallacoglu, Sergio Fantini

Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155

Amanda Civiletto, Daniel E. Weiner

Tufts Medical Center, 800 Washington Street, Boston, Massachusetts 02111

J. Biomed. Opt. 19(2), 026005 (Feb 12, 2014). doi:10.1117/1.JBO.19.2.026005
History: Received September 23, 2013; Revised January 8, 2014; Accepted January 10, 2014
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Abstract.  We present a pilot clinical application of coherent hemodynamics spectroscopy (CHS), a technique to investigate cerebral hemodynamics at the microcirculatory level. CHS relies on frequency-resolved measurements of induced cerebral hemodynamic oscillations that are measured with near-infrared spectroscopy (NIRS) and analyzed with a hemodynamic model. We have used cyclic inflation (200 mmHg) and deflation of a pneumatic cuff placed around the subject’s thigh at seven frequencies in the range of 0.03 to 0.17 Hz to generate CHS spectra and to obtain a set of physiological parameters that include the blood transit times in the cerebral microcirculation, the cutoff frequency for cerebral autoregulation, and blood volume ratios across the three different compartments. We have investigated five hemodialysis patients, during the hemodialysis procedure, and six healthy subjects. We have found that the blood transit time in the cerebral microcirculation is significantly longer in hemodialysis patients with respect to healthy subjects. No significant differences were observed between the two groups in terms of autoregulation efficiency and blood volume ratios. The demonstration of the applicability of CHS in a clinical setting and its sensitivity to the highly important cerebral microcirculation may open up new opportunities for NIRS applications in research and in medical diagnostics and monitoring.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Michele L. Pierro ; Jana M. Kainerstorfer ; Amanda Civiletto ; Daniel E. Weiner ; Angelo Sassaroli, et al.
"Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study", J. Biomed. Opt. 19(2), 026005 (Feb 12, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.2.026005


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