Research Papers: Imaging

Compressed sensing based virtual-detector photoacoustic microscopy in vivo

[+] Author Affiliations
Jing Meng

Qufu Normal University, College of Computer Science, 80 Yantai Road North, Rizhao 276826, China

Chengbo Liu

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China

Jiaxiang Zheng

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China

Riqiang Lin

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China

Liang Song

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 1068 Xueyuan Boulevard, Shenzhen 518055, China

J. Biomed. Opt. 19(3), 036003 (Mar 05, 2014). doi:10.1117/1.JBO.19.3.036003
History: Received December 28, 2013; Revised January 28, 2014; Accepted January 29, 2014
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Abstract.  Photoacoustic microscopy (PAM) is becoming a vital tool for various biomedical studies, including functional and molecular imaging of cancer. However, due to the use of a focused ultrasonic transducer for photoacoustic detection, the image quality of conventional PAM degrades rapidly away from the ultrasonic focal zone. To improve the image quality of PAM for out-of-focus regions, we have developed compressed sensing based virtual-detector photoacoustic microscopy (CS-PAM). Through phantom and in vivo experiments, it has been demonstrated that CS-PAM can effectively extend the depth of focus of PAM, and thus may greatly expand its potential biomedical applications.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Jing Meng ; Chengbo Liu ; Jiaxiang Zheng ; Riqiang Lin and Liang Song
"Compressed sensing based virtual-detector photoacoustic microscopy in vivo", J. Biomed. Opt. 19(3), 036003 (Mar 05, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.3.036003


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