Special Section on Selected Topics in Biophotonics: Optical Coherence Tomography and Biomolecular Imaging with Coherent Raman Scattering Microscopy

Robust estimation of cerebral hemodynamics in neonates using multilayered diffusion model for normal and oblique incidences

[+] Author Affiliations
Idan Steinberg

Tel-Aviv University, Laboratory for Optics and Lasers in Medicine, Department of Biomedical Engineering, Haim Levanon Street 55, P.O. Box 39040, Tel Aviv 6997801, Israel

Osnat Harbater

Tel-Aviv University, Laboratory for Optics and Lasers in Medicine, Department of Biomedical Engineering, Haim Levanon Street 55, P.O. Box 39040, Tel Aviv 6997801, Israel

Israel Gannot

Tel-Aviv University, Laboratory for Optics and Lasers in Medicine, Department of Biomedical Engineering, Haim Levanon Street 55, P.O. Box 39040, Tel Aviv 6997801, Israel

J. Biomed. Opt. 19(7), 071406 (Mar 06, 2014). doi:10.1117/1.JBO.19.7.071406
History: Received November 20, 2013; Revised January 15, 2014; Accepted January 27, 2014
Text Size: A A A

Abstract.  The diffusion approximation is useful for many optical diagnostics modalities, such as near-infrared spectroscopy. However, the simple normal incidence, semi-infinite layer model may prove lacking in estimation of deep-tissue optical properties such as required for monitoring cerebral hemodynamics, especially in neonates. To answer this need, we present an analytical multilayered, oblique incidence diffusion model. Initially, the model equations are derived in vector-matrix form to facilitate fast and simple computation. Then, the spatiotemporal reflectance predicted by the model for a complex neonate head is compared with time-resolved Monte Carlo (TRMC) simulations under a wide range of physiologically feasible parameters. The high accuracy of the multilayer model is demonstrated in that the deviation from TRMC simulations is only a few percent even under the toughest conditions. We then turn to solve the inverse problem and estimate the oxygen saturation of deep brain tissues based on the temporal and spatial behaviors of the reflectance. Results indicate that temporal features of the reflectance are more sensitive to deep-layer optical parameters. The accuracy of estimation is shown to be more accurate and robust than the commonly used single-layer diffusion model. Finally, the limitations of such approaches are discussed thoroughly.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Idan Steinberg ; Osnat Harbater and Israel Gannot
"Robust estimation of cerebral hemodynamics in neonates using multilayered diffusion model for normal and oblique incidences", J. Biomed. Opt. 19(7), 071406 (Mar 06, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.071406


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.