Research Papers: Imaging

Targeted zwitterionic near infrared fluorescent probe for improved imaging of type 2 cannabinoid receptors

[+] Author Affiliations
Zhiyuan Wu

University of Pittsburgh, Department of Radiology, Molecular Imaging Laboratory, Pittsburgh, Pennsylvania 15219

Shanghai Jiao Tong University, School of Medicine, Ruijin Hospital, Department of Radiology, Shanghai 200025, China

Pin Shao

University of Pittsburgh, Department of Radiology, Molecular Imaging Laboratory, Pittsburgh, Pennsylvania 15219

Shaojuan Zhang

University of Pittsburgh, Department of Radiology, Molecular Imaging Laboratory, Pittsburgh, Pennsylvania 15219

Xi’an Jiaotong University, the First Hospital of Medical School, Department of Diagnostic Radiology, Xi’an, Shaanxi 710061, China

Mingfeng Bai

University of Pittsburgh, Department of Radiology, Molecular Imaging Laboratory, Pittsburgh, Pennsylvania 15219

University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232

J. Biomed. Opt. 19(3), 036006 (Mar 06, 2014). doi:10.1117/1.JBO.19.3.036006
History: Received December 30, 2013; Revised January 27, 2014; Accepted January 30, 2014
Text Size: A A A

Abstract.  Recent studies indicate that the type 2 cannabinoid receptors (CB2R) have become an attractive target for treating a variety of pathologies, including cancers, neurodegenerative diseases, inflammation, pain, osteoporosis, immunological disorders and drug abuse. In addition, it appears that many of these diseases have up-regulated CB2R expression. However, the precise role of CB2R in the regulation of diseases remains unclear. The ability to specifically image CB2R would contribute to develop reliable CB2R-based therapeutic approaches with a better understanding of the mechanism of CB2R action in these diseases. We developed a CB2R-targeted zwitterionic near-infrared (NIR) fluorescent probe, ZW760-mbc94. When compared with a previously reported CB2R probe (NIR760-mbc94) with the same targeting moiety but a charged NIR fluorescent dye, ZW760-mbc94 showed improved binding specificity in vitro and ex vivo. Overall, ZW760-mbc94 appears to have great potential as a CB2R-targeted contrast agent.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Zhiyuan Wu ; Pin Shao ; Shaojuan Zhang and Mingfeng Bai
"Targeted zwitterionic near infrared fluorescent probe for improved imaging of type 2 cannabinoid receptors", J. Biomed. Opt. 19(3), 036006 (Mar 06, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.3.036006


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.