Research Papers: General

Dependence of optical scattering from Intralipid in gelatin-gel based tissue-mimicking phantoms on mixing temperature and time

[+] Author Affiliations
Puxiang Lai, Xiao Xu, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri 63130-4899

J. Biomed. Opt. 19(3), 035002 (Mar 06, 2014). doi:10.1117/1.JBO.19.3.035002
History: Received December 3, 2013; Revised February 11, 2014; Accepted February 12, 2014
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Abstract.  Intralipid is widely used as an optical scattering agent in tissue-mimicking phantoms. Accurate control when using Intralipid is critical to match the optical diffusivity of phantoms to the prescribed value. Currently, most protocols of Intralipid-based hydrogel phantom fabrication focus on factors such as Intralipid brand and concentration. In this note, for the first time to our knowledge, we explore the dependence of the optical reduced scattering coefficient (at 532 nm optical wavelength) on the temperature and the time of mixing Intralipid with gelatin-water solution. The studied samples contained 1% Intralipid and were measured with oblique-incidence reflectometry. It was found that the reduced scattering coefficient increased when the Intralipid-gelatin-water mixture began to solidify at room temperature. For phantoms that had already solidified completely, the diffusivity was shown to be significantly influenced by the temperature and the duration of the mixing course. The dependence of the measured diffusivity on the mixing conditions was confirmed by experimental observations. Moreover, the mechanism behind the dependence behavior is discussed.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Topics

Scattering ; Tissues ; Water

Citation

Puxiang Lai ; Xiao Xu and Lihong V. Wang
"Dependence of optical scattering from Intralipid in gelatin-gel based tissue-mimicking phantoms on mixing temperature and time", J. Biomed. Opt. 19(3), 035002 (Mar 06, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.3.035002


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