Research Papers: General

Diffusion model for ultrasound-modulated light

[+] Author Affiliations
Joseph L. Hollmann

Northeastern University, Department of Electrical and Computer Engineering, 409 Dana Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115

Gordon Center for Subsurface Sensing and Imaging Systems (CenSSIS), 360 Huntington Avenue, 302 Stearns Center, Boston, Massachusetts 02115

Roarke Horstmeyer, Changhuei Yang

California Institute of Technology, Department of Electrical Engineering, 1200 E. California Blvd. Mail Code 136-93, Pasadena, California 91125

Charles A. DiMarzio

Northeastern University, Department of Electrical and Computer Engineering, 409 Dana Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115

Gordon Center for Subsurface Sensing and Imaging Systems (CenSSIS), 360 Huntington Avenue, 302 Stearns Center, Boston, Massachusetts 02115

Northeastern University, Department of Mechanical and Industrial Engineering, 334 Snell Engineering Center, 360 Huntington Avenue, Boston, Massachusetts 02115

J. Biomed. Opt. 19(3), 035005 (Mar 17, 2014). doi:10.1117/1.JBO.19.3.035005
History: Received September 29, 2013; Revised January 29, 2014; Accepted January 30, 2014
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Abstract.  Researchers use ultrasound (US) to modulate diffusive light in a highly scattering medium like tissue. This paper analyzes the US–optical interaction in the scattering medium and derives an expression for the US-modulated optical radiance. The diffusion approximation to the radiative transport equation is employed to develop a Green’s function for US-modulated light. The predicted modulated fluence and flux are verified using finite-difference time-domain simulations. The Green’s function is then utilized to illustrate the modulated reflectance as the US–optical interaction increases in depth. The intent of this paper is to focus on high US frequencies necessary for high-resolution imaging because they are of interest for applications such as phase conjugation.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Joseph L. Hollmann ; Roarke Horstmeyer ; Changhuei Yang and Charles A. DiMarzio
"Diffusion model for ultrasound-modulated light", J. Biomed. Opt. 19(3), 035005 (Mar 17, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.3.035005


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