Research Papers: Imaging

Multispectral optoacoustic tomography at 64, 128, and 256 channels

[+] Author Affiliations
Alexander Dima, Vasilis Ntziachristos

Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg 85764, Germany

Technische Universität München, Department of Medicine and Department of Electrical Engineering and Information Technology, Chair for Biological Imaging, Arcisstrasse 21, Munich 80333, Germany

Neal C. Burton

iThera Medical GmbH, Zielstattstrasse 13, Munich 81379, Germany

J. Biomed. Opt. 19(3), 036021 (Mar 27, 2014). doi:10.1117/1.JBO.19.3.036021
History: Received October 9, 2013; Revised January 27, 2014; Accepted February 25, 2014
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Abstract.  Optoacoustic (photoacoustic) imaging has already showcased the capacity to offer high-resolution small animal visualization in vivo in a variety of cancer, cardiovascular, or neuroimaging applications. In particular, multispectral optoacoustic tomography (MSOT) has shown imaging along the spectral and the time dimensions, enabling sensing of multiple molecules over time and, more recently, in real time. Furthermore, cross-sectional imaging of at least 20 mm diameter has been showcased in vivo in animals and humans using 64-element curved transducers placed along a single curved line. Herein, we investigated the imaging improvements gained by utilizing a larger number of detectors and inquired whether more detectors will result in measurable image quality improvements. For this reason, we implemented MSOT using 64-, 128-, and 256-element transducers and imaged the same phantoms and animals under similar conditions. Further, corroborated by numerical simulation analysis, our findings quantify the improvements in resolution and overall image quality for the increasing number of detectors used pointing to significant improvements in image quality for the 256 detector array, over 64 or 128 detectors.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Alexander Dima ; Neal C. Burton and Vasilis Ntziachristos
"Multispectral optoacoustic tomography at 64, 128, and 256 channels", J. Biomed. Opt. 19(3), 036021 (Mar 27, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.3.036021


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