Research Papers: Sensing

Double-pass Mach–Zehnder fiber interferometer pH sensor

[+] Author Affiliations
Zhi Qiang Tou

Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, Singapore 637457, Singapore

Chi Chiu Chan

Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, Singapore 637457, Singapore

Jesmond Hong

Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, Singapore 637457, Singapore

Shermaine Png

Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, Singapore 637457, Singapore

Khay Ming Tan Eddie

EINST Technology Pte Ltd, 1092 Lower Delta Road #04-01, Singapore 169203, Singapore

Terence Aik Huang Tan

Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, Singapore 637457, Singapore

J. Biomed. Opt. 19(4), 047002 (Apr 10, 2014). doi:10.1117/1.JBO.19.4.047002
History: Received December 4, 2013; Revised March 14, 2014; Accepted March 17, 2014
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Abstract.  A biocompatible fiber-optic pH sensor based on a unique double-pass Mach–Zehnder interferometer is proposed. pH responsive poly(2-hydroxyethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate) hydrogel coating on the fiber swells/deswells in response to local pH, leading to refractive index changes that manifest as shifting of interference dips in the optical spectrum. The pH sensor is tested in spiked phosphate buffer saline and demonstrates high sensitivity of 1.71nm/pH, pH 0.004 limit of detection with good responsiveness, repeatability, and stability. The proposed sensor has been successfully applied in monitoring the media pH in cell culture experiments to investigate the relationship between pH and cancer cell growth.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Zhi Qiang Tou ; Chi Chiu Chan ; Jesmond Hong ; Shermaine Png ; Khay Ming Tan Eddie, et al.
"Double-pass Mach–Zehnder fiber interferometer pH sensor", J. Biomed. Opt. 19(4), 047002 (Apr 10, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.4.047002


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