Research Papers: Imaging

Diffuser-aided time-domain diffuse optical imaging: a phantom study

[+] Author Affiliations
Chia-Wei Sun

National Chiao Tung University, Department of Photonics, Biomedical Optical Imaging Lab, Hsinchu 30010, Taiwan

Ching-Cheng Chuang

National Chiao Tung University, Department of Photonics, Biomedical Optical Imaging Lab, Hsinchu 30010, Taiwan

Chia-Yen Lee

National United University, Department of Electrical Engineering, Miaoli 36003, Taiwan

Chung-Ming Chen

National Taiwan University, Institute of Biomedical Engineering, Taipei 10617, Taiwan

J. Biomed. Opt. 19(4), 046008 (Apr 10, 2014). doi:10.1117/1.JBO.19.4.046008
History: Received October 15, 2013; Revised January 16, 2014; Accepted February 26, 2014
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Abstract.  We present the first experimental results of time-resolved diffuser-aided diffuse optical imaging (DADOI) method in this paper. A self-manufactured diffuser plate was inserted between the optode and the surface of a scattering medium. The diffuser was utilized to enhance the multiple scattering that destroys the image information for baseline measurement of turbid medium. Therefore, the abnormality can be detected with the modified optical density calculation. The time-domain DADOI method can provide better imaging contrast and simpler imaging than the conventional diffuse optical tomography measurement. Besides, it also reveals rich depth information with temporal responses. Therefore, the DADOI offers a great potential to detect the breast tumor and chemotherapy monitoring in clinical diagnosis.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Chia-Wei Sun ; Ching-Cheng Chuang ; Chia-Yen Lee and Chung-Ming Chen
"Diffuser-aided time-domain diffuse optical imaging: a phantom study", J. Biomed. Opt. 19(4), 046008 (Apr 10, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.4.046008


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