Research Papers: Imaging

Fast vascular component of cortical spreading depression revealed in rats by blood pulsation imaging

[+] Author Affiliations
Victor Teplov

University of Eastern Finland, Department of Applied Physics, P.O. Box 1627, Yliopistonranta 1 F, 70210 Kuopio, Finland

Artem Shatillo

University of Eastern Finland, Department of Neurobiology, A. I. Virtanen Institute, P.O. Box 1627, Neulaniementie 2, 70211 Kuopio, Finland

Ervin Nippolainen

University of Eastern Finland, Department of Applied Physics, P.O. Box 1627, Yliopistonranta 1 F, 70210 Kuopio, Finland

Olli Gröhn

University of Eastern Finland, Department of Neurobiology, A. I. Virtanen Institute, P.O. Box 1627, Neulaniementie 2, 70211 Kuopio, Finland

Rashid Giniatullin

University of Eastern Finland, Department of Neurobiology, A. I. Virtanen Institute, P.O. Box 1627, Neulaniementie 2, 70211 Kuopio, Finland

Kazan Federal University, Lab of Neurobiology, Kazan 420000, Russia

Alexei A. Kamshilin

University of Eastern Finland, Department of Applied Physics, P.O. Box 1627, Yliopistonranta 1 F, 70210 Kuopio, Finland

J. Biomed. Opt. 19(4), 046011 (Apr 11, 2014). doi:10.1117/1.JBO.19.4.046011
History: Received October 28, 2013; Revised March 21, 2014; Accepted March 25, 2014
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Abstract.  Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of neurons and glia and has a less characterized vascular component. CSD is a commonly used phenomenon to test new methods of live brain imaging. Application of a blood pulsations imaging (BPI) technique to study of CSD induced with high-potassium solution in rat cortex allowed us to visualize for the first time the novel vascular component of a CSD wave. In our study, this wave component propagated in the limited part of the cortex along the bow-shaped trajectory in sharp contrast with concentric development of CSD measured by concurrently applied optical intrinsic signal (OIS) imaging technique. It was associated with a significant increase of the blood pulsations amplitude (BPA), started with a delay of 20 to 90 s comparing to signal measured with OIS, and propagated 40% faster than OIS signal. These findings suggest that the BPA and slower change of the cerebral blood volume are not directly related to each other even though both characterize the same vascular system. Our study indicates that the BPI technique could be used for characterization of the new pulsatile vascular component of CSDs in animal models of migraine, stroke, and brain trauma.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Topics

Blood ; Animals

Citation

Victor Teplov ; Artem Shatillo ; Ervin Nippolainen ; Olli Gröhn ; Rashid Giniatullin, et al.
"Fast vascular component of cortical spreading depression revealed in rats by blood pulsation imaging", J. Biomed. Opt. 19(4), 046011 (Apr 11, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.4.046011


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