Research Papers: Imaging

Possibilities of optical imaging of the Tc99m-based radiopharmaceuticals

[+] Author Affiliations
Anton K. Kondakov

Pirogov Russian National Research Medical University, Department of Radiology and Radiotherapy, 1 Ostrovityanova Street, Moscow 117997, Russian Federation

Ilya L. Gubskiy

Pirogov Russian National Research Medical University, Department of Medical Nanobiotechnology, 1 Ostrovityanova Street, Moscow 117997, Russian Federation

Igor A. Znamenskiy

Pirogov Russian National Research Medical University, Department of Radiology and Radiotherapy, 1 Ostrovityanova Street, Moscow 117997, Russian Federation

Central Clinical Hospital of the Russian Academy of Sciences, 12 b.3 Fotievoy Street, Moscow 119333, Russian Federation

Vladimir P. Chekhonin

Pirogov Russian National Research Medical University, Department of Medical Nanobiotechnology, 1 Ostrovityanova Street, Moscow 117997, Russian Federation

Serbsky State Research Center of Social and Forensic Psychiatry, Division of Fundamental and Applied Neurobiology, 23 b.2 Kropotkinskiy per., Moscow 119034, Russian Federation

J. Biomed. Opt. 19(4), 046014 (Apr 21, 2014). doi:10.1117/1.JBO.19.4.046014
History: Received February 3, 2014; Revised March 22, 2014; Accepted March 25, 2014
Text Size: A A A

Abstract.  In vivo optical imaging is widely used in preclinical studies. Recently, the application of optical imaging systems for preclinical visualization of gamma-emitting isotopes has become of interest since the evaluation of various organs relies on Tc99m-based radiopharmaceuticals (RPs). In vitro radioluminescence of Tc99m-based RPs, including pertechnetate, albumin macroaggregates, dimercaptosuccinic acid, phytate colloid, and ethylenediamine tetramethylene phosphonic acid, was studied with IVIS Spectrum CT™ optical imaging system. The distribution of phytate colloid was also studied in vivo with and without scintillating materials and the results were compared with those obtained with a conventional scintigraphy. The visible light emission appeared to be due to the radioluminescence of water and luminophores contained in RPs rather than from Cherenkov radiation. Weak air luminescence affected the background. The radioluminescence of fluids induced by Tc99m-based tracers could be detected using charge-coupled device optical imaging systems. The radioluminescence intensity and its spectral distribution depend on the surrounding fluid and known luminophores present. Thus, in some cases the in vivo optical imaging is possible but the use of scintillator, e.g., borosilicate glass or bismuth germanate, is preferred.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Anton K. Kondakov ; Ilya L. Gubskiy ; Igor A. Znamenskiy and Vladimir P. Chekhonin
"Possibilities of optical imaging of the Tc99m-based radiopharmaceuticals", J. Biomed. Opt. 19(4), 046014 (Apr 21, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.4.046014


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.