Research Papers: Imaging

Mueller matrix decomposition for determination of optical rotation of glucose molecules in turbid media

[+] Author Affiliations
Ping Sun

Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China

Yongchao Ma

Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China

Wei Liu

Capital Normal University, Department of Physics, Beijing 100048, China

Qinghua Yang

Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China

Qiongzhen Jia

Beijing Normal University, Department of Physics, Beijing Area Major Laboratory of Applied Optics, Beijing 100875, China

J. Biomed. Opt. 19(4), 046015 (Apr 25, 2014). doi:10.1117/1.JBO.19.4.046015
History: Received August 12, 2013; Revised February 17, 2014; Accepted March 24, 2014
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Abstract.  The optical activity of glucose molecules is important for diagnosing and monitoring blood glucose of diabetes. In order to accurately detect the diabetes at an early stage, there is an urgent need to develop innovative detection methods. By use of Mueller matrix decomposition (MMD), we have studied the optical activity of glucose molecules in three types of turbid media—polystyrene (PST) sphere suspension, chicken blood, and the vein blood of diabetic patients. The experimental setup to obtain the Mueller matrix in the forward detection geometry has been used. The experimental results show that the rotation angle has linear relationship with the concentration of the glucose when the scattering coefficient of the PST sphere suspension remains unchanged, whereas the scattering effect enlarges the rotation angle. Furthermore, optical rotation abides by Drude’s dispersion equation. The decomposition method has also been found useful applications in quantifying the optical rotations of blood glucose in diabetic patients. The diabetic severity status can be distinguished with the rotation angle of glucose and also is in accordance with the clinical diagnosis. Thus, the method of MMD has promising applications in diabetic diagnosis and monitoring.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Ping Sun ; Yongchao Ma ; Wei Liu ; Qinghua Yang and Qiongzhen Jia
"Mueller matrix decomposition for determination of optical rotation of glucose molecules in turbid media", J. Biomed. Opt. 19(4), 046015 (Apr 25, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.4.046015


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