Research Papers: Imaging

Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples

[+] Author Affiliations
Wenfeng Wang

Nanyang Technological University, School of Chemical and Biomedical Engineering, Nanyang Avenue, Singapore 637457, Singapore

Lee Guan Lim

National University Health System, Division of Gastroenterology and Hepatology, Kent Ridge Road, Singapore 119228, Singapore

Supriya Srivastava

National University of Singapore, Cancer Science Institute, Lower Kent Ridge Road, Singapore 117599, Singapore

Jimmy So Bok Yan

National University of Singapore, Department of Surgery, Lower Kent Ridge Road, Singapore 119228, Singapore

Asim Shabbir

National University of Singapore, Cancer Science Institute, Lower Kent Ridge Road, Singapore 117599, Singapore

Quan Liu

Nanyang Technological University, School of Chemical and Biomedical Engineering, Nanyang Avenue, Singapore 637457, Singapore

J. Biomed. Opt. 19(4), 046020 (Apr 28, 2014). doi:10.1117/1.JBO.19.4.046020
History: Received December 8, 2013; Revised March 25, 2014; Accepted March 31, 2014
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Abstract.  Multispectral Mueller matrix imaging was performed over a spectral range from 470 to 632 nm on 4-μm unstained gastric tissue sections. A complete set of polarization parameters was derived. The combination of linear depolarization and linear retardance yields the highest accuracy in sample classification. When the depolarization of linearly polarized light due to scattering is independent of the orientation angle of the incident linear polarization vector, the derivation of linear polarization properties will require only 3×3 Mueller matrix, which would significantly reduce the complexity of the polarimetry imaging system. When additional parameters are needed to complement the two linear polarization parameters, retardance, circular depolarization, and depolarization can be included in classification in the order of preference. However, these additional parameters would require the measurement of 4×4 Mueller matrix. In addition, it appears that wavelength is not a critical factor in terms of classification accuracy for thin tissue sections in this study.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Wenfeng Wang ; Lee Guan Lim ; Supriya Srivastava ; Jimmy So Bok Yan ; Asim Shabbir, et al.
"Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples", J. Biomed. Opt. 19(4), 046020 (Apr 28, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.4.046020


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