Research Papers: Imaging

Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study

[+] Author Affiliations
Dan Savastru, Sorin Miclos

National Institute of Optoelectronics, 409 Atomistilor Street, Magurele, Ilfov, RO-077125, Romania

Ernest W. Chang, Ankit Patel, Nicusor Iftimia

Physical Sciences Inc., 20 New England Business Center Drive, Andover, Massachusetts 01810

Martha B. Pitman

Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114

J. Biomed. Opt. 19(5), 056001 (May 01, 2014). doi:10.1117/1.JBO.19.5.056001
History: Received February 4, 2014; Revised April 3, 2014; Accepted April 7, 2014
Text Size: A A A

Abstract.  This study aimed to evaluate the concept of using high-resolution optical coherence tomography (OCT) imaging to rapidly assess surgical specimens and determine if cancer positive margins were left behind in the surgical bed. A mouse model of breast cancer was used in this study. Surgical specimens from 30 animals were investigated with OCT and automated interpretation of the OCT images was performed and tested against histopathology findings. Specimens from 10 animals were used to build a training set of OCT images, while the remaining 20 specimens were used for a validation set of images. The validation study showed that automated interpretation of OCT images can differentiate tissue types and detect cancer positive margins with at least 81% sensitivity and 89% specificity. The findings of this pilot study suggest that OCT imaging of surgical specimens and automated interpretation of OCT data may enable in the future real-time feedback to the surgeon about margin status in patients with breast cancer, and potentially with other types of cancers. Currently, such feedback is not provided and if positive margins are left behind, patients have to undergo another surgical procedure. Therefore, this approach can have a potentially high impact on breast surgery outcome.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Dan Savastru ; Ernest W. Chang ; Sorin Miclos ; Martha B. Pitman ; Ankit Patel, et al.
"Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study", J. Biomed. Opt. 19(5), 056001 (May 01, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.5.056001


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.