Research Papers: Sensing

Monitoring brain temperature by time-resolved near-infrared spectroscopy: pilot study

[+] Author Affiliations
Mohammad Fazel Bakhsheshi, Keith St. Lawrence, Ting-Yim Lee

Lawson Health Research Institute, Imaging Program, London, Ontario N6A 4V2, Canada

Robarts Research Institute, Imaging Research Laboratories, London, Ontario N6A 5B7, Canada

Western University, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada

Mamadou Diop

Lawson Health Research Institute, Imaging Program, London, Ontario N6A 4V2, Canada

Western University, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada

J. Biomed. Opt. 19(5), 057005 (May 09, 2014). doi:10.1117/1.JBO.19.5.057005
History: Received February 14, 2014; Revised April 6, 2014; Accepted April 8, 2014
Text Size: A A A

Abstract.  Mild hypothermia (HT32°C33°C) is an effective neuroprotective strategy for a variety of acute brain injuries. However, the wide clinical adaptation of HT3233°C has been hampered by the lack of a reliable noninvasive method for measuring brain temperature, since core measurements have been shown to not always reflect brain temperature. The goal of this work was to develop a noninvasive optical technique for measuring brain temperature that exploits both the temperature dependency of water absorption and the high concentration of water in brain (80%–90%). Specifically, we demonstrate the potential of time-resolved near-infrared spectroscopy (TR-NIRS) to measure temperature in tissue-mimicking phantoms (in vitro) and deep brain tissue (in vivo) during heating and cooling, respectively. For deep brain tissue temperature monitoring, experiments were conducted on newborn piglets wherein hypothermia was induced by gradual whole body cooling. Brain temperature was concomitantly measured by TR-NIRS and a thermocouple probe implanted in the brain. Our proposed TR-NIRS method was able to measure the temperature of tissue-mimicking phantoms and brain tissues with a correlation of 0.82 and 0.66 to temperature measured with a thermometer, respectively. The mean difference between the TR-NIRS and thermometer measurements was 0.15°C±1.1°C for the in vitro experiments and 0.5°C±1.6°C for the in vivo measurements.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Mohammad Fazel Bakhsheshi ; Mamadou Diop ; Keith St. Lawrence and Ting-Yim Lee
"Monitoring brain temperature by time-resolved near-infrared spectroscopy: pilot study", J. Biomed. Opt. 19(5), 057005 (May 09, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.5.057005


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.