Special Section on Selected Topics in Biophotonics: Optical Coherence Tomography and Biomolecular Imaging with Coherent Raman Scattering Microscopy

Physical and mathematical modeling of antimicrobial photodynamic therapy

[+] Author Affiliations
Lisa Bürgermeister

Fraunhofer Institute for Laser Technology, Steinbachstr. 15, Aachen D-52074, Germany

Fernando Romero López

Fraunhofer Institute for Laser Technology, Steinbachstr. 15, Aachen D-52074, Germany

Wolfgang Schulz

Fraunhofer Institute for Laser Technology, Steinbachstr. 15, Aachen D-52074, Germany

J. Biomed. Opt. 19(7), 071411 (May 21, 2014). doi:10.1117/1.JBO.19.7.071411
History: Received September 20, 2013; Revised March 18, 2014; Accepted April 22, 2014
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Abstract.  Antimicrobial photodynamic therapy (aPDT) is a promising method to treat local bacterial infections. The therapy is painless and does not cause bacterial resistances. However, there are gaps in understanding the dynamics of the processes, especially in periodontal treatment. This work describes the advances in fundamental physical and mathematical modeling of aPDT used for interpretation of experimental evidence. The result is a two-dimensional model of aPDT in a dental pocket phantom model. In this model, the propagation of laser light and the kinetics of the chemical reactions are described as coupled processes. The laser light induces the chemical processes depending on its intensity. As a consequence of the chemical processes, the local optical properties and distribution of laser light change as well as the reaction rates. The mathematical description of these coupled processes will help to develop treatment protocols and is the first step toward an inline feedback system for aPDT users.

© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Lisa Bürgermeister ; Fernando Romero López and Wolfgang Schulz
"Physical and mathematical modeling of antimicrobial photodynamic therapy", J. Biomed. Opt. 19(7), 071411 (May 21, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.071411


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