Research Papers: Imaging

Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain

[+] Author Affiliations
Kyle P. Nadeau

Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

Anthony J. Durkin

Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

Bruce J. Tromberg

Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

J. Biomed. Opt. 19(5), 056013 (May 23, 2014). doi:10.1117/1.JBO.19.5.056013
History: Received March 14, 2014; Revised April 30, 2014; Accepted May 5, 2014
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Abstract.  We have developed a method for extracting spatial frequency information content from biological tissue, which is used to calculate tissue optical properties and determine tissue structural orientation. This demodulation method employs a two-dimensional Hilbert transform using a spiral phase function in Fourier space. The approach presented here allows for the determination of tissue optical properties using a single frame of data for each modulation frequency, increasing imaging speed by two to threefold versus conventional, three-phase spatial frequency domain imaging (SFDI). This new single-phase Hilbert transform approach recovers optical property and scattering orientation index values within 1% and 10% of three-phase SFDI, respectively. These results suggest that, using the Hilbert demodulation technique, SFDI data acquisition speed can be increased significantly while preserving data quality, which will help us move forward toward the implementation of a real-time SFDI platform.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Kyle P. Nadeau ; Anthony J. Durkin and Bruce J. Tromberg
"Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain", J. Biomed. Opt. 19(5), 056013 (May 23, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.5.056013


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