Research Papers: Sensing

Noninvasive assessment of the risk of tobacco abuse in oral mucosa using fluorescence spectroscopy: a clinical approach

[+] Author Affiliations
Shaiju S. Nazeer

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing, Biophotonics and Imaging Laboratory, Poojappura, Thiruvananthapuram 695 012, Kerala, India

Mar Ivanios College, Department of Physics, Thiruvananthapuram 695 015, Kerala, India

Rajashekharan Asish

Government Dental College, Department of Oral Medicine and Radiology, Thiruvananthapuram 695 011, Kerala, India

Chandrashekharan Venugopal

Government Dental College, Department of Oral Medicine and Radiology, Thiruvananthapuram 695 011, Kerala, India

General Hospital, Kerala Health Services, Trivandrum, Kerala, India

Balan Anita

Government Dental College, Department of Oral Medicine and Radiology, Thiruvananthapuram 695 011, Kerala, India

Government Dental College, Department of Oral Medicine and Radiology, Kozhikkode 673 008, Kerala, India

Arun Kumar Gupta

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing, Biophotonics and Imaging Laboratory, Poojappura, Thiruvananthapuram 695 012, Kerala, India

National Institute of Mental Health and Neuro Sciences, Department of Neuroimaging and Interventional Radiology, Bangalore 560029, Karnataka, India

Ramapurath S. Jayasree

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing, Biophotonics and Imaging Laboratory, Poojappura, Thiruvananthapuram 695 012, Kerala, India

J. Biomed. Opt. 19(5), 057013 (May 28, 2014). doi:10.1117/1.JBO.19.5.057013
History: Received January 17, 2014; Revised April 29, 2014; Accepted May 1, 2014
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Abstract.  Tobacco abuse and alcoholism cause cancer, emphysema, and heart disease, which contribute to high death rates, globally. Society pays a significant cost for these habits whose first demonstration in many cases is in the oral cavity. Oral cavity disorders are highly curable if a screening procedure is available to diagnose them in the earliest stages. The aim of the study is to identify the severity of tobacco abuse, in oral cavity, as reflected by the emission from endogenous fluorophores and the chromophore hemoglobin. A group who had no tobacco habits and another with a history of tobacco abuse were included in this study. To compare the results with a pathological condition, a group of leukoplakia patients were also included. Emission from porphyrin and the spectral filtering modulation effect of hemoglobin were collected from different sites. Multivariate analysis strengthened the spectral features with a sensitivity of 60% to 100% and a specificity of 76% to 100% for the discrimination. Total hemoglobin and porphyrin levels of habitués and leukoplakia groups were comparable, indicating the alarming situation about the risk of tobacco abuse. Results prove that fluorescence spectroscopy along with multivariate analysis is an effective noninvasive tool for the early diagnosis of pathological changes due to tobacco abuse.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Shaiju S. Nazeer ; Rajashekharan Asish ; Chandrashekharan Venugopal ; Balan Anita ; Arun Kumar Gupta, et al.
"Noninvasive assessment of the risk of tobacco abuse in oral mucosa using fluorescence spectroscopy: a clinical approach", J. Biomed. Opt. 19(5), 057013 (May 28, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.5.057013


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