Research Papers: Therapeutic

New eye phantom for ophthalmic surgery

[+] Author Affiliations
Gessica Fogli

University of Pisa, Research Centre “E. Piaggio,” Largo Lucio Lazzarino 1, Pisa 56126, Italy

Gianni Orsi

University of Pisa, Research Centre “E. Piaggio,” Largo Lucio Lazzarino 1, Pisa 56126, Italy

University of Pisa, Department of Ingegneria Civile e Industriale, Largo Lucio Lazzarino 1, Pisa 56126, Italy

Carmelo De Maria

University of Pisa, Research Centre “E. Piaggio,” Largo Lucio Lazzarino 1, Pisa 56126, Italy

University of Pisa, Department of Ingegneria dell’Informazione, Via G. Caruso 16, Pisa 56126, Italy

Francesca Montemurro

University of Pisa, Research Centre “E. Piaggio,” Largo Lucio Lazzarino 1, Pisa 56126, Italy

Michele Palla

Azienda Ospedaliera Universitaria Pisana-Cisanello, Eye Surgery Clinic, Via Paradisa 2, Pisa 56124, Italy

Stanislao Rizzo

Azienda Ospedaliera Universitaria Pisana-Cisanello, Eye Surgery Clinic, Via Paradisa 2, Pisa 56124, Italy

Giovanni Vozzi

University of Pisa, Research Centre “E. Piaggio,” Largo Lucio Lazzarino 1, Pisa 56126, Italy

University of Pisa, Department of Ingegneria dell’Informazione, Via G. Caruso 16, Pisa 56126, Italy

J. Biomed. Opt. 19(6), 068001 (Jun 02, 2014). doi:10.1117/1.JBO.19.6.068001
History: Received October 21, 2013; Revised May 12, 2014; Accepted May 12, 2014
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Abstract.  In this work, we designed and realized a new phantom able to mimic the principal mechanical, rheological, and physical cues of the human eye and that can be used as a common benchmark to validate new surgical procedures, innovative vitrectomes, and as a training system for surgeons. This phantom, in particular its synthetic humor vitreous, had the aim of reproducing diffusion properties of the natural eye and can be used as a system to evaluate the pharmacokinetics of drugs and optimization of their dose, limiting animal experiments. The eye phantom was built layer-by-layer starting from the sclera up to the retina, using low cost and easy to process polymers. The validation of the phantom was carried out by mechanical characterization of each layer, by diffusion test with commercial drugs into a purposely developed apparatus, and finally by a team of ophthalmic surgeons. Experiments demonstrated that polycaprolactone, polydimethylsiloxane, and gelatin, properly prepared, are the best materials to mimic the mechanical properties of sclera, choroid, and retina, respectively. A polyvinyl alcohol-gelatin polymeric system is the best for mimicking the viscosity of the human humor vitreous, even if the bevacizumab half-life is lower than in the human eye.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Gessica Fogli ; Gianni Orsi ; Carmelo De Maria ; Francesca Montemurro ; Michele Palla, et al.
"New eye phantom for ophthalmic surgery", J. Biomed. Opt. 19(6), 068001 (Jun 02, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.6.068001


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