Research Papers: Sensing

Sensitivity correction for the influence of the fat layer on muscle oxygenation and estimation of fat thickness by time-resolved spectroscopy

[+] Author Affiliations
Etsuko Ohmae, Motoki Oda, Hiroaki Suzuki, Toshihiko Suzuki, Yutaka Yamashita

Hamamatsu Photonics K.K., Central Research Laboratory, 5000 Hirakuchi, Hamakita-ku, Hamamatsu, Shizuoka 434-8601, Japan

Shinichiro Nishio, Hiroshi Watanabe

Hamamatsu University School of Medicine, Department of Clinical Pharmacology and Therapeutics, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan

Kyoichi Ohashi

Oita University Faculty of Medicine, Department of Clinical Pharmacology and Therapeutics, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan

Shunsaku Koga

Kobe Design University, Applied Physiology Laboratory, 8-1-1 Gakuennishi-machi, Nishi-ku, Kobe 651-2196, Japan

J. Biomed. Opt. 19(6), 067005 (Jun 09, 2014). doi:10.1117/1.JBO.19.6.067005
History: Received December 27, 2013; Revised May 13, 2014; Accepted May 15, 2014
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Abstract.  Near-infrared spectroscopy (NIRS) has been used for noninvasive assessment of oxygenation in living tissue. For muscle measurements by NIRS, the measurement sensitivity to muscle (SM) is strongly influenced by fat thickness (FT). In this study, we investigated the influence of FT and developed a correction curve for SM with an optode distance (3 cm) sufficiently large to probe the muscle. First, we measured the hemoglobin concentration in the forearm (n=36) and thigh (n=6) during arterial occlusion using a time-resolved spectroscopy (TRS) system, and then FT was measured by ultrasound. The correction curve was derived from the ratio of partial mean optical path length of the muscle layer LM to observed mean optical path length L. There was good correlation between FT and L at rest, and L could be used to estimate FT. The estimated FT was used to validate the correction curve by measuring the forearm blood flow (FBF) by strain-gauge plethysmography (SGP_FBF) and TRS (TRS_FBF) simultaneously during a reactive hyperemia test with 16 volunteers. The corrected TRS_FBF results were similar to the SGP_FBF results. This is a simple method for sensitivity correction that does not require use of ultrasound.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Etsuko Ohmae ; Shinichiro Nishio ; Motoki Oda ; Hiroaki Suzuki ; Toshihiko Suzuki, et al.
"Sensitivity correction for the influence of the fat layer on muscle oxygenation and estimation of fat thickness by time-resolved spectroscopy", J. Biomed. Opt. 19(6), 067005 (Jun 09, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.6.067005


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