Research Papers: Sensing

Photoacoustic resonance spectroscopy for biological tissue characterization

[+] Author Affiliations
Fei Gao

Nanyang Technological University, School of Electrical and Electronic Engineering, 50 Nanyang Avenue, 639798 Singapore

Xiaohua Feng

Nanyang Technological University, School of Electrical and Electronic Engineering, 50 Nanyang Avenue, 639798 Singapore

Yuanjin Zheng

Nanyang Technological University, School of Electrical and Electronic Engineering, 50 Nanyang Avenue, 639798 Singapore

Claus-Dieter Ohl

Nanyang Technological University, School of Physical and Mathematical Sciences, 50 Nanyang Avenue, 639798 Singapore

J. Biomed. Opt. 19(6), 067006 (Jun 13, 2014). doi:10.1117/1.JBO.19.6.067006
History: Received March 6, 2014; Revised May 6, 2014; Accepted May 19, 2014
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Abstract.  By “listening to photons,” photoacoustics allows the probing of chromosomes in depth beyond the optical diffusion limit. Here we report the photoacoustic resonance effect induced by multiburst modulated laser illumination, which is theoretically modeled as a damped mass-string oscillator and a resistor-inductor-capacitor (RLC) circuit. Through sweeping the frequency of multiburst modulated laser, the photoacoustic resonance effect is observed experimentally on phantoms and porcine tissues. Experimental results demonstrate different spectra for each phantom and tissue sample to show significant potential for spectroscopic analysis, fusing optical absorption and mechanical vibration properties. Unique RLC circuit parameters are extracted to quantitatively characterize phantom and biological tissues.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Fei Gao ; Xiaohua Feng ; Yuanjin Zheng and Claus-Dieter Ohl
"Photoacoustic resonance spectroscopy for biological tissue characterization", J. Biomed. Opt. 19(6), 067006 (Jun 13, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.6.067006


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