JBO Letters

Ear swelling test by using laser speckle imaging with a long exposure time

[+] Author Affiliations
Vyacheslav Kalchenko, Yuri Kuznetsov, Alon Harmelin

Weizmann Institute of Science, Department of Veterinary Resources, Rehovot 76100, Israel

Dina Preise

Weizmann Institute of Science, Department of Plant Sciences, Rehovot 76100, Israel

Igor Meglinski

University of Otago, Department of Physics, PO Box 56, Dunedin 9054, New Zealand

J. Biomed. Opt. 19(6), 060502 (Jun 26, 2014). doi:10.1117/1.JBO.19.6.060502
History: Received March 16, 2014; Revised May 30, 2014; Accepted June 2, 2014
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Abstract.  Laser speckle imaging with long exposure time has been applied noninvasively to visualize the immediate reaction of cutaneous vessels in mice in response to a known primary irritant and potential allergen—methyl salicylate. The compound has been used topically on the surface of the pinna and the reaction of the vascular network was examined. We demonstrate that irritant-induced acute vascular reaction can be effectively and accurately detected by laser speckle imaging technique. The current approach holds a great promise for application in routine screening of the cutaneous vascular response induced by contact agents, screenings of mouse ear swelling test, and testing the allergenic potential of new synthetic materials and healthcare pharmaceutical products.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Vyacheslav Kalchenko ; Yuri Kuznetsov ; Dina Preise ; Igor Meglinski and Alon Harmelin
"Ear swelling test by using laser speckle imaging with a long exposure time", J. Biomed. Opt. 19(6), 060502 (Jun 26, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.6.060502


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